We grouped these features into four clinically interpretable categories: “demographics” (e.g., sex, race, age), “atopic status” (e.g., blood IgE level, positive allergen skin prick test, history of hay fever), “lung function” (e.g., pre-BD FEV1%pred, ratio of FEV1 over forced vital capacity (FVC)) and “recent asthma exacerbations” (emergency room (ER) or hospitalization for asthma). Here, IGHE is linked to seasonal allergic rhinitis.