Bmal1 promotes AML progression through ferroptosis suppression by facilitating enhancer of zeste 2 polycomb repressive complex 2 subunit(EZH2)-mediated methylation of EBF transcription factor 3(EBF3) promoter and downregulating EBF3 and ALOX15, which is required for lipid peroxidation that contributes to ferroptosis. This evidence concerns the gene BMAL1 and acute myeloid leukemia.