Bmal1 promotes AML progression through ferroptosis suppression by facilitating enhancer of zeste 2 polycomb repressive complex 2 subunit(EZH2)-mediated methylation of EBF transcription factor 3(EBF3) promoter and downregulating EBF3 and ALOX15, which is required for lipid peroxidation that contributes to ferroptosis. The gene discussed is EZH2; the disease is acute myeloid leukemia.