ART also induces ferroptosis in MM through overexpressing ACSL4 and reducing GPX4 expression, furthermore, ART inhibits the nuclear localization of sterol regulatory element-binding protein 2 (SREBP2), which is accompanied by downregulation of isopentenyl pyrophosphate (IPP) and GPX4, ultimately triggering ferroptosis in myeloma cells [166]. This evidence concerns the gene GPX4 and plasma cell myeloma.