SHPK and Miyoshi myopathy: Shikonin (SHK), a major bioactive component found in the roots of Lithospermum erythrorhizon, exhibits dual functions in MM cells as a proteasome inhibitor and necroptosis inducer, and Li et al. [163] reported that SHK induced ferroptosis in MM by evoking oxidative stress, enhancing ferrous iron levels, and increasing lipid peroxidation, in which treatment with ferroptosis inhibitors reversed SHK-induced cell death.