In addition, Tian et al. [93] identified five ferroptosis-associated hub genes in T-cell ALL through a protein-protein interaction (PPI) network, and found that Lipocalin2(LCN2) was highly expressed in T-ALL, and knockdown of LCN2 could enhance RSL3-induced ferroptosis, characterized by increased iron, malondialdehyde (MDA), COX2 levels and decrease of GSH and GPX4 levels. Here, GPX4 is linked to acute lymphoblastic leukemia.