A recent study revealed that lactate enhances H3K18 lactylation (H3K18la) at the METTL3 promoter, modulating m6A methylation and subsequently promoting ACSL4 expression, which induces ferroptosis and exacerbates acute lung injury associated with sepsis [23], suggesting a potential link between lactate, H3K18la, lung injury and ferroptosis. Here, ACSL4 is linked to Sepsis.