Among the top ten predicted genes, defined as genes not previously reported as significantly associated with HF, AF or MI according to DisGeNET, a comprehensive gene–disease association database integrating information from ClinVar, GWAS Catalog, UniProt, Orphanet and published literature, five were identified as druggable (AR, APP, GATA2, EGR1 and EP300). The gene discussed is EP300; the disease is atrial fibrillation.