GATA2 and hydrops fetalis: Among the top ten predicted genes, defined as genes not previously reported as significantly associated with HF, AF or MI according to DisGeNET, a comprehensive gene–disease association database integrating information from ClinVar, GWAS Catalog, UniProt, Orphanet and published literature, five were identified as druggable (AR, APP, GATA2, EGR1 and EP300).