In TCGA database, CLDN4 was highly expressed in CESC, CHOL, PCPG and endometrial carcinoma (UCEC), and the integration of GTEx database demonstrated that the expression level of CLDN4 was also markedly up-regulated in CESC, CHOL, PCPG and UCEC. Here, CLDN4 is linked to endometrial carcinoma.