Among the 13 LDLR homologs (including LDLR, VLDLR, LRP1, LRP2, LRP3, LRP4, LRP5, LRP6, LRP8, LRP10, LRP11, LRP12, and LRPAP1), only the knockdown or knockout of LRP8 effectively inhibited viral infection. The gene discussed is LRP8; the disease is viral infectious disease.