Among the 13 LDLR homologs (including LDLR, VLDLR, LRP1, LRP2, LRP3, LRP4, LRP5, LRP6, LRP8, LRP10, LRP11, LRP12, and LRPAP1), only the knockdown or knockout of LRP8 effectively inhibited viral infection. This evidence concerns the gene LDLR and viral infectious disease.