The importance of these analyses is further clarified by the widespread realisation that YAP and TAZ hyperactivation plays key roles in multiple cancer types (45, 70, 77, 79, 121, 122), including in the frequent NF2 loss-of-function mutations in both pleural mesothelioma, a deadly cancer originating in the mesothelial lining of the lung (70, 123, 124, 125), and schwannomas, tumours of the nervous system (126, 127, 128, 129). This evidence concerns the gene NF2 and cancer.