TARDBP and Alzheimer disease: Pathological protein aggregation marks the progression of neurodegenerative diseases (NDDs), with TDP-43 forming protein aggregates in post-mortem brains in 97% of Amyotrophic Lateral Sclerosis (ALS), 40% of Frontotemporal Dementia (FTD), and many cases of Alzheimer’s and Alzheimer’s Related Dementias (AD/ADRD).