Figure 2 illustrates the interaction effects between time and obesity status, showing the longitudinal changes in salivary CatS, BOP, PPD, and CAL from baseline to the third month after NSPT. When comparing the changes in clinical parameters between the two groups after NSPT, the reductions in BOP, PPD, and CAL were significantly greater in the nonobese periodontitis group than in the obese group (p < 0.001). In addition, the decrease in salivary CatS levels following NSPT was significantly greater in the nonobese periodontitis group (p < 0.001). Here, PIMREG is linked to obesity due to melanocortin 4 receptor deficiency.