CYP2D6 and injury: To investigate the physiological significance of enhanced CYP2D6 expression, we assessed the cytotoxic effects of five drugs from the Drug-Induced Liver Injury (DILI) Rank dataset—perhexiline, troglitazone, amiodarone, trazodone, and tramadol—all known for their potential to cause drug-induced liver injury, in both WT and CYP2D6-enhanced cells (Table 2).