The qPCR results demonstrated that FABP3 (P < 0.001), PECR (P < 0.01), and OPN3 (P < 0.001) expression markedly increased in D‐gal‐induced sarcopenia compared with control groups, whereas PCTP (P < 0.001), SREBF2 (P < 0.001), and PPARGC1A (P < 0.05) levels dramatically decreased. The gene discussed is OPN3; the disease is sarcopenia.