Since Ppara∆KPT mice, during fasting, showed hepatic micro‐steatosis with further lipid accumulation, lower serum glucose levels, and increased transcription of muscle catabolism‐related genes than those in Pparafl/fl controls, impaired activation of PPARα in PT in patients with CKD could cause the development of such systemic complications. Here, PPARA is linked to chronic kidney disease.