Although the exact function of Trem2 in various diseases is not fully understood, several studies on Trem2 have focused on the CNS, demonstrating that the overexpression of Trem2 can suppress the inflammatory response in animal models of AD, multiple sclerosis, Parkinson’s disease, and other neurodegenerative diseases [12, 13, 29]. Here, TREM2 is linked to Alzheimer disease.