Overrepresented motifs in DKO males, including AR, FOXA1, FOXA2, NRF2, and PPARγ (Li et al., 2012; Koga et al., 2001; Ma et al., 2014; Schaefer et al., 2005; Zhang et al., 2015), correlated with tumor-promoting functions (Figure 2—source data 2). Here, PPARG is linked to neoplasm.