SNCA-KO SK-Mel-28 xenografted clones also showed reduced tumor growth in mice, which was associated with decreased TfR1, and iron exporter ferroportin (FPN1), along with increased levels of ferritin, the divalent metal ion transporter 1 (DMT1), Fe (III), and apoptosis (TUNEL staining) compared to control melanoma xenografts [70]. The gene discussed is TFRC; the disease is melanoma.