In the study presented by Stergiou et al., the association of lymphadenopathy with the presence of anti-SSA or anti-SSB antibodies, lymphopenia, greater focus score, symptomatic spotting and occupation of the peripheral nervous system was demonstrated, (Stergiou et al. 2022) which supports the view that lymphadenopathy is associated with greater pSS activity. This evidence concerns the gene SSB and Lymphadenopathy.