INS and obesity due to melanocortin 4 receptor deficiency: The DISTAL-study, a 12-week randomized, placebo-controlled trial, was the first study to investigate the effects of potato fiber and sugar beet pectin supplementation within the context of a high-protein (±45% plant-based protein) diet on peripheral insulin sensitivity (IS) in individuals with overweight/obesity and at increased risk of developing T2D.