SCN3A and microcephaly: For instance, SCN3A encodes a sodium channel, and specific missense mutations of it are associated with the MCD polymicrogyria (PMG) (Smith et al., 2018), while genetic manipulations of ASPM have also been shown to produce severe microcephaly in human and ferret brains (Johnson et al., 2018), while disrupting TMEM161B leads to cortical malformations in humans and ferrets (Akula et al., 2023b).