Our findings are in sharp contrast with previously reported results showing large benefits of tamoxifen on force generation during submaximal contractions in preclinical mouse models of CNM, with mutations in Mtm1, Bin1 and Dnm2 genes, as well as in dystrophic mice (Gineste et al., 2023; Gayi et al., 2018; Maani et al., 2018; Dorchies et al., 2013). The gene discussed is BIN1; the disease is centronuclear myopathy.