KLF5 and breast cancer: Long noncoding RNA A study has found that PVT1 plays a crucial role in the development of triple‐negative breast cancer (TNBC) by promoting the signaling pathway involving KLF5 and beta‐catenin. Through the action of EZH2, PVT1 was found to silence the expression of FOXF1, leading to increased cell proliferation and decreased apoptosis in breast cancer.