In Alzheimer’s disease (AD), rafts serve as pathological platforms for aberrant Aβ metabolism: by clustering β- and γ-secretases, they enhance amyloidogenic APP cleavage, and their dynamic reorganization disrupts autophagic–lysosomal degradation, impeding Aβ clearance and accelerating neurodegeneration (Cordy et al., 2006; Zhang et al., 2019). The gene discussed is APP; the disease is Alzheimer disease.