A newly emerging syndrome, hypotonia, ataxia, developmental delay, and tooth enamel defects syndrome (HADDTS) is linked to a de novo heterozygous missense mutation in the CTBP1 gene (NM_001328.2: c.1024C → T, p.Arg342Trp) (Acosta-Baena et al., 2022; Beck et al., 2016; Beck et al., 2019). Here, CTBP1 is linked to Global developmental delay.