Mutations affecting the NADPH oxidase complex, including CYBB, CYBA, NCF1, and NCF2, compromise neutrophil function and the production of reactive oxygen species, predisposing patients to chronic granulomatous disease (CGD) and heightened susceptibility to BCGosis (Li et al., 2016; Reetika et al., 2020) (32, 34). The gene discussed is CYBB; the disease is chronic granulomatous disease.