SCGB1A1 and chronic obstructive pulmonary disease: Although previous Mendelian randomization studies using SCGB1A1-linked SNPs have demonstrated that genetically elevated CC16 levels may causally reduce COPD risk and progression, our study provides the first evidence of a significant association between the SCGB1A1 rs3741240 polymorphism and COPD susceptibility in the Indian population.