No significant differences were observed in trigger distributions (p = 0.790) when comparing periods before and after January 1, 2020 (designated as the pandemic onset reference), however, post-pandemic elevations occurred in inflammatory markers (white blood cell count (WBC), neutrophils, CRP, IL-6, PCT), comorbidities (pulmonary disease (18.3% vs. 10.2%; p = 0.002), arrhythmia (8.87% vs. 4.17%; p = 0.016)) and overall complications, particularly concurrent infections (31.7% vs. 17.2%; p< 0.001), though pulmonary infections remained unchanged (Supplementary Table 3). The gene discussed is CRP; the disease is lung disorder.