Analyses of CD31-positive vessels by immunohistochemistry revealed a significant decrease in CD31-positive vessels per 0,25 mm2 in the treated group when compared to controls (from 34.3 ± 9.95 to 5.2 ± 0.89 CD31+ vessels per area), indicating a marked decrease in tumor vascularization (p < 0.05, Figures 2A, B). Here, PECAM1 is linked to neoplasm.