Furthermore, in myocardial infarction models, a hypoxic milieu induces M2-like macrophages to express V-set and Immunoglobulin Domain Containing 4 (VSIG4), consequently facilitating the transformation of cardiac fibroblasts into myofibroblasts and leading to cardiac fibrosis (186). The gene discussed is VSIG4; the disease is myocardial infarction.