NFKB1 and neoplasm: Furthermore, the lncRNA HOTTIP carried by M1 exosomes competitively binds to miR-19a-3p/miR-19b-3p, activating the TLR5/NF-κB pathway, which not only suppresses head and neck cancer progression but also polarizes circulating monocytes into an anti-tumor M1 phenotype (309).