Similarly, GeoMx-based spatial multi-omics analysis of postmortem pancreatic samples from COVID-19 patients revealed spatial clustering of pro-inflammatory macrophages that mediate β-cell pyroptosis through the TNFSF12/TNFRSF12A signaling axis; furthermore, a human vascularized macrophage-islet organoid model was developed to effectively simulate immune-mediated cell damage (326). Here, TNFRSF12A is linked to COVID-19.