Engineered exosomes derived from M1 macrophages, displaying IL4R-targeting peptides and loaded with NF-κB p50 siRNA and miR-511-3p, specifically bind to the IL-4 receptor on TAMs, promoting their reprogramming toward an M1 phenotype, enhancing anti-tumor immunity, and suppressing tumor growth (301). This evidence concerns the gene NFKB1 and neoplasm.