Although the classification of CXCL17 as a GPR35 ligand remains controversial, recent studies demonstrate that the CXCL17-GPR35 axis mediates myeloid-derived suppressor cell recruitment during liver ischemia-reperfusion injury (43) and activates IL-17 signaling to promote chemoresistance in CRC (44). The gene discussed is GPR35; the disease is ischemia.