Emerging evidence identifies BTG2 as a molecular link between diabetic kidney disease (DKD) and PD, where it modulates autophagy via mTORC1 pathway inhibition, potentially suppressing epithelial-mesenchymal transition (EMT) (58).It is noteworthy that the mTORC1 pathway not only regulates autophagy but also modulates the activation of the NF-κB signaling pathway (59), which itself plays a critical regulatory role in both inflammatory responses and osteoclast differentiation in periodontitis (60). Here, NFKB1 is linked to periodontitis.