GATA3 and allergic asthma: Th2 dominance is a hallmark of allergic asthma, driven by epithelial and antigen-presenting cells (APCs) cues that favor IL-4/IL-13 programs under GATA3/STAT6 (GATA Binding Protein 3/Signal Transducer and Activator of Transcription 6) control, whereas insufficient or ineffective Th1 activity can coexist with severe disease and contribute to steroid-insensitive features in selected contexts (9–11).