Intriguingly, we found that expression levels of Ptgs1, Cxcl9, Cxcl10, as well as Ctnnb1 (encoding β-catenin) and β-catenin target genes Axin2 and Ccnd1 were significantly increased, while DC chemokine CXCL12 was down-regulated in advanced iCCA tissues compared with early-stage iCCAs (Supplementary Figures S2A-D). Here, AXIN2 is linked to infantile convulsions and choreoathetosis.