In addition, in the setting of allogeneic hematopoietic stem cell transplantation (allo-HCT), Treg depletion of the graft (via CD25 depletion) has been shown to exacerbate graft-versus-host disease (GVHD), a life-threatening complication of allo-HCT during which donor immune cells attack host healthy tissues (4, 5) (6, 7). The gene discussed is IL2RA; the disease is graft versus host disease.