Additionally, the active ingredients in P. ginseng, 20(R)-ginsenoside Rg3 enhances the expression of Bcl-2 and Bcl-XL and decreases the levels of Bax, cleaved-caspase-3, and caspase-8 in STZ-induced DKD mice (101). The gene discussed is CASP3; the disease is diabetic kidney disease.