Peripheral inflammation is a well-established trigger of delirium (Maclullich et al., 2008), and IL-1, IL-1β, IL-6, IL-8, tumor necrosis factor (TNF), and prostaglandin E2 (PGE2) stimuli trigger tissue macrophage and blood monocyte activation and secretion of inflammatory mediators (Sajjad et al., 2020; Cape et al., 2014; Hoogland et al., 2015). The gene discussed is TNF; the disease is delirium.