TGFBR1 and Familial prostate cancer: Additionally, TDEVs can promote regulatory T cell (Treg) expansion, with ZNF667-AS1 in prostate cancer cell-derived TDEVs inhibiting PC cell growth and docetaxel resistance by destabilizing TGFBR1 mRNA in CD4+ T cells through interaction with U2AF1, thereby reducing TGFBR1 expression and weakening Treg expansion (Jiang et al., 2021).