Prostate cancer-derived TDEVs contain circFMN2, which, upon binding to HuR, reduces the HuR-KLF2 interaction, inhibits KLF2 expression, and subsequently decreases RNF128 transcription, collectively promoting tumor cell proliferation, invasion, and migration (Huang et al., 2023). This evidence concerns the gene ELAVL1 and Familial prostate cancer.