Furukawa et al. (2004) similarly reported reduced antioxidant enzyme activity in adipose tissue of obese mice, highlighting the link between oxidative stress and obesity. Elevated C-reactive protein (CRP), a marker of systemic inflammation, further underscores the inflammatory milieu in obesity (Visser et al., 1999) (Figure 2). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.