Serum IL-6 concentrations are elevated after exercise, and IL-6 subsequently reaches the intestinal tract, leading to increased levels of Glucagon-like peptide-1(GLP-1) through stimulation of intestinal L-cells, which contribute to the relief of anxiety disorders and memory disorders (Do et al., 2025; Ellingsgaard et al., 2011; Liu et al., 2024). The gene discussed is GCG; the disease is anxiety disorder.