MCAM and rheumatoid arthritis: Additionally, VECs_Mcam exhibited enrichment in rheumatoid arthritis, IL-17 signaling, and TNF signaling pathways (Figure 10E, p < 0.05; see also Supplementary Figure S6), suggesting that VECs_Col15a1 may be involved in stress sensing and transduction, while VECs_Mcam likely contributes to inflammatory initiation.