KCNIP4 and spondylitis: RO/E indices further indicated a positive association of Mac_Adam8 (1.59) and Mac_mt-Co1 (1.64) with arthritis and spondylitis, whereas Mac_Kcnip4 (0.38), Mac_Retnla (0.08), Mac_Spic (0.64), and Mac_Vsig4 (0.52) were negatively correlated (Figure 5B, p < 0.05).