The top 40 differentially expressed genes showed in Supplementary Figure S2A, and the KEGG analysis showed that the pathway of Hif-1 signaling (marker genes of Ctla4, Hif1a, Serpine1, Timp1), Rheumatoid arthritis (Ctla4, Mmp3, Tcirg1), ECM-receptor interaction (Itga5, Lamb1), IL-17 signaling (Mmp3, S100a8, S100a9) were influenced (Figure 3A), which suggested that K. pintolopesii activates these pathways in the T cells of ZAP70W163C mutant mice. The gene discussed is CTLA4; the disease is rheumatoid arthritis.