For instance, In diabetic foot ulcers, the NET release of neutrophils in diabetic wound tissue is regulated by the NLRP3/caspase-1/GSDMD pathway, and the use of disulfiram to inhibit GSDMD can suppress this pathway, reducing NET formation and thus accelerating diabetic wound healing (Yang et al., 2023). This evidence concerns the gene GSDMD and diabetic foot.