RARRES2 and neoplasm: Similar interplay occurs in OSCC: VAP-1 downregulation hinders tumor growth by reducing NF-κB/IL-8 signaling and neutrophil infiltration (Xu et al., 2022), while Chemerin activates the JAK2/STAT3 pathway in OSCC cells via TANs, upregulating phosphorylated retinoblastoma, E2F transcription factor 1, cyclin E1/D1 (crucial cell cycle protein) to drive proliferation and metastasis (Hu et al., 2022).