AKT1 and neoplasm: For instance, N2-type TANs fuel tumor growth via ROS, which activates pro-survival pathways (NF-κB, PI3K/Akt/mTOR) in cancer cells, promotes angiogenesis, suppresses anti-tumor immunity (T cells, NK cells), and can cause DNA damage (Arfin et al., 2021; Sionov, 2021).