Owing to its high sensitivity, rapid kinetics, and temporal resolution, HBP has shown superior diagnostic performance compared to traditional markers such as C-reactive protein (CRP) in a range of infectious diseases, including sepsis and pneumonia (Taha et al., 2024; Kyriazopoulou et al., 2024; Bateman et al., 2016). The gene discussed is CRP; the disease is Sepsis.