For example, in Hodgkin lymphoma (HL), upregulation of the transcription factor interferon regulatory factor 5 (IRF5) is driven by transcriptional activation induced by an altered epigenetic state of open and hypomethylated endogenous retroviral LOR1a long terminal repeat (LTR) that are normally dormant upstream of IRF5 (Babaian et al., 2016). This evidence concerns the gene IRF5 and Hodgkins lymphoma.