METTL16 and neoplasm: METTL16 influences various stages of gene expression through its m6A modification activity.8, 9, 10 Aberrant expression of METTL16 has been closely linked to tumor proliferation, invasion, metastasis, and resistance to chemotherapy.11, 12, 13, 14, 15 Depending on the context, METTL16 can either promote or inhibit tumorigenesis by regulating the expression of key oncogenes and tumor suppressor genes.