METTL16 and thyroid gland papillary carcinoma: ,59 Conversely, lower METTL16 expression is observed in pancreatic ductal adenocarcinoma,34,60 endometrial cancer,61,62 epithelial ovarian cancer,63 papillary thyroid carcinoma,15,64 and urothelial carcinoma,65 which are associated with poor prognosis.