In hepatocellular carcinoma, the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 signaling axis has been shown to regulate interactions between tumor cells and the tumor microenvironment, particularly influencing cell behaviors such as epithelial–mesenchymal transition (Fig. 5). The gene discussed is METTL16; the disease is hepatocellular carcinoma.