,128 In gliomas, a strong positive correlation has been observed between METTL16 and nuclear factor erythroid-derived 2-like 2 (NFE2L2), with NFE2L2 also being positively correlated with M2-type macrophages and other immune checkpoints, such as tumor necrosis factor superfamily member 4 (TNFSF4), programmed cell death protein 1 (PDCD1), cluster of differentiation 244 (CD244), and inducible T cell co-stimulator (ICOS) (Fig. 5). The gene discussed is ICOS; the disease is glioma.