,59 Conversely, lower METTL16 expression is observed in pancreatic ductal adenocarcinoma,34,60 endometrial cancer,61,62 epithelial ovarian cancer,63 papillary thyroid carcinoma,15,64 and urothelial carcinoma,65 which are associated with poor prognosis. The gene discussed is METTL16; the disease is differentiated thyroid carcinoma.