This finding strengthens the association of circFKBP8(5S,6) and its encoded protein cFKBP8 with DRD3 and autophagy, and provides an experimental basis for a more comprehensive interpretation and understanding of the involvement of circFKBP8(5S,6) and its encoded protein cFKBP8 in the pathogenesis of MDD, and provides a new way of thinking for finding precise targets for the treatment of MDD. The gene discussed is DRD3; the disease is major depressive disorder.