Several studies have suggested that MDD may be related to the inhibition of the AMPK/mTOR signaling pathway, and some antidepressant drugs and therapies exert their antidepressant effects through the activation of autophagy via the AMPK signaling pathway.40, 41, 42 Autophagy, a lysosomal degradation pathway, is essential for maintaining neuronal homeostasis.43 The gene discussed is MTOR; the disease is major depressive disorder.