PAK1 exerts profound effects on promoting the proliferation, migration, and invasion of CRC, both in vitro and in vivo, through regulating the MAPK, PI3K/AKT, Rho GTPase, and WNT/β-catenin pathways.5, 6, 7, 8 PAK1 modulates diverse downstream signaling cascades that govern critical cellular processes such as cell adhesion, cytoskeleton reorganization, and the epithelial-to-mesenchymal transition.9 The gene discussed is PAK1; the disease is colorectal carcinoma.