Our in vivo experiments further demonstrated that HLWDD reduced serum LDL-C, TC, TG, GLU, BUN, and CRE levels in T2DM model rats while down-regulating EGFR, PTEN, MDM2, TRAF6, CCL5, and Caspase-3 expression. Here, TRAF6 is linked to type 2 diabetes mellitus.