Tumor necrosis factor receptor-associated molecule 6 (TRAF6), a key adaptor in inflammatory signaling, mediates activation of the TRAF6/TAK1/NF-κB cascade in response to hyperglycemia-induced immune stimulation, thereby promoting TNF-α, IL-1β, and IL-6 expression (71), This pathway contributes to diabetic renal fibrosis and functional impairment through epithelial-mesenchymal transition (EMT). The gene discussed is IL1B; the disease is Hyperglycemia.