Based on the degree values, the top 10 core targets were MMP1, IGFBP3, MMP2, MMP9, HSPA5, GSK3B, TNF, EGFR, IL6, and GAPDH, suggesting their potential in mediating fraxin’s impact in NAFLD management. The gene discussed is GSK3B; the disease is metabolic dysfunction-associated steatotic liver disease.