Based on the degree values, the top 10 core targets were MMP1, IGFBP3, MMP2, MMP9, HSPA5, GSK3B, TNF, EGFR, IL6, and GAPDH, suggesting their potential in mediating fraxin’s impact in NAFLD management. Here, IGFBP3 is linked to metabolic dysfunction-associated steatotic liver disease.