Paeoniflorin, a monoterpene glycoside extracted from the roots of Paeonia lactiflora, can significantly promote the differentiation of CD4+CD25+Foxp3+ Tregs and suppress the production of Th17 cells, restoring the Th17/Treg balance for the treatment of inflammatory bowel disease (IBD). The gene discussed is IL2RA; the disease is inflammatory bowel disease.