In patients with ankylosing spondylitis, curcumin significantly increases the number of Tregs, enhances the expression of transforming growth factor-β (TGF-β) and interleukin-10 (IL-10), and suppresses interleukin-6 (IL-6) levels (Ahmadi et al., 2020). This evidence concerns the gene IL6 and ankylosing spondylitis.