FOXP3 and neoplasm: For instance, Curcumin and Glycyrrhizin (from Glycyrrhiza uralensis) display opposite effects on Tregs across different disease backgrounds: in autoimmune or inflammatory conditions, they can promote Treg differentiation and Foxp3 expression to restore immune tolerance; whereas in tumor models, they often suppress Treg accumulation in the tumor microenvironment, thereby activating anti-tumor immunity.