Comparing the S1 and the C1 groups, the S1 group had a slower resolution of correction of the acidemia (14.8±9.5 S1 vs 10.8±5.7 C1, hours; p<0.01), a longer duration of insulin infusion (28.1±11.7 S1 vs 21.8±25.8 C1, hours; p<0.01), a longer hospital length of stay (5.9±5.3 S1 vs 3.4±4.5 C1, days; p<0.01), and an increased incidence of hypoglycemia (30% S1 vs 10% C1; p<0.01). No difference was observed in the time to serum bicarbonate ≥18 mEq/L (p=0.16) or the incidence of hypokalemia (p=0.72) in the S1 group compared to C1. The gene discussed is INS; the disease is Hypokalemia.