Several studies have established that NT-proBNP is an important biomarker mainly synthesized and secreted by myocytes in the left ventricle (LV) as a response to myocytes stretched by pressure overload or volume expansion of the ventricle and is a powerful predictor of cardiovascular outcomes. In this retrospective study, our aim was to evaluate the association between admission NT-proBNP levels and the duration of hospital stay in patients with HF and to identify clinical predictors of elevated NT-proBNP and adverse in-hospital outcomes. This evidence concerns the gene NPPB and hydrops fetalis.