In acute, florid neuroinflammation (NORSE/FIRES), short-course IL-1 or IL-6 blockade has shown clinical signals in series and case reports, and could serve as an induction layer that rapidly suppresses cytokine surges; subsequent maintenance might then rely on agents with narrower systemic immunosuppressive footprints, such as C5aR1 antagonists or BBB-focused approaches, to consolidate network stabilization while infection risk is deescalated. The gene discussed is IL1B; the disease is infection.