PPIB and pneumocystosis: Clinical practice outside epilepsy informs a consistent mitigation bundle: complete age-appropriate and pathogen-specific vaccination before complement or cytokine inhibitors when possible; screen for hepatitis B with serologies and initiate nucleos(t)ide prophylaxis in at-risk patients; avoid live vaccines while on biologics; and institute Pneumocystis jirovecii pneumonia (PJP) when corticosteroids ≥20 mg prednisone-equivalent are used for greater than or equal to four weeks alongside another immunosuppressant.